https://www.adanguyenx.com/blog daily 0.75 2025-06-22 https://www.adanguyenx.com/blog/longevity-l2ntg monthly 0.5 2023-08-09 https://www.adanguyenx.com/blog/partial-reprogramming monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799744-GEIRKT6LQ1GEIT6QPHBB/PartialReprogramming.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out A map of reprogramming companies’ progress and approach https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799687-QXHAW80LBKCEOF5097Y0/histone.jpeg Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Histone and DNA. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799706-A9C0O05JUZ0HDVM1Y3HX/fibroblast+correlation.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Dynamics of epigenetic age and fibroblast identity expression over a 49-day reprogramming time course. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799541-0G7HAUXVY3AQEOLEGTLS/Frame+1.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out How different terms used to describe partial reprogramming relate to each other https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799559-MULYAV0G9Z5AZEX8KM7V/reprogrammable-mice.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out How reprogrammable mice are made. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799694-H2BZ7WLJV4RDVR3UYUAL/Roux+correlation.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Left: pooled screening of OSKM combinations on mesenchymal stem cells. Right: adipogenic cells. NT means “not treated”. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799548-0P9921Z5KGW886UK6FVF/OSKM+system.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out The OSKM system https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799731-B8LDTNN6X0SD824RVCCD/Gill+CpG.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Partially reprogrammed fibroblasts dedifferentiate then reacquire their initial cellular identity in their methylomes. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799532-SYGASSWOZ1NCG601OZ3D/timeline.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out A history of partial reprogramming. See full list of papers here. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799575-FOZ8QEONTN34R8DQNWK2/PCA.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out PCAs from Chondronasiou 2022 and Sarkar 2020 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799713-5MFZ1DEJTA8VUJ5LGXVB/Roux+result.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Partially reprogrammed mesenchymal stem cells are predicted to return to control cell identities in RNA velocity analysis. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799723-375FR3DMX6R8EVC5NFHB/Gill+protocol.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out OSKM induction protocol in Gill 2021 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799738-FCGH7MH567RJT5GATRBR/gill+diff.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Difference in epigenetic age between negative controls and treated cells. Chart made from data in Gill 2021. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799758-8C5X24H965JAH0F626KN/turn+indications.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Turn’s target indications. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799583-X0K3FW8FIVSR4AVENBSQ/distribution+of+effects.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Distribution of partial reprogramming effects across different types of tissues. Y-axis denotes the number of studies. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799749-ORKUMG2S53AR4O4VBPI8/shift+gene+clock.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out How Shift’s gene clock enables discovery of alternative OSKM factors. Image credit. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799567-995LL4Q4MKJ3VGVCU0WO/lifespan.png Blog - Partial reprogramming deep dive: the good, bad, and partially unresolved - Make it stand out Kaplan-Meier curve. The gray curve is the control, and the blue and red curves are treated mice. Image credit. https://www.adanguyenx.com/blog/a-history-of-partial-reprogramming monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799481-0NSDU2FMR934FWGSE4W0/Frame+10+%283%29.png Blog - A history of partial reprogramming: a semi-comprehensive list of papers - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.adanguyenx.com/blog/seeking-intensity monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799779-J79AB9OGDDDOE3I9R5IK/https___bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com_public_images_3049b7b5-4fe7-40e6-bbdd-702290ca7188_1456x903.jpeg Blog - Seeking intensity - Make it stand out (Credit: Wellness Wisdom) https://www.adanguyenx.com/blog/on-not-overthinking monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799519-VFV2UT5XZIISGPD2OP1V/https___bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com_public_images_f067bbc7-ff72-4e85-8919-6e5db8e74acc_886x499.jpeg Blog - On not overthinking - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799516-ZT1NJULXDF2RXGJJAEPU/EvunkwFXcAAotvp.jpeg Blog - On not overthinking - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.adanguyenx.com/blog/living-the-life-you-choose monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799502-8T2HDAONJ3J894C8CQB4/https___bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com_public_images_b497eb63-f86a-4f67-99fb-a61937467cf7_982x340.png Blog - Living the life you choose - Make it stand out Smoky Mountains, Meteor Crater, Grand Canyon https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799499-YJBZ3YCC3UUCT6YDCRSP/https___bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com_public_images_db1bb2e6-63e3-424d-988c-aefa9da8bca0_1683x385.png Blog - Living the life you choose - Make it stand out Changing views from the car, from East to West https://www.adanguyenx.com/blog/dont-try-to-cure-cancer monthly 0.5 2025-07-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574799492-I7K9XLSGB6GSDUYM3420/Screen+Shot+2021-03-17+at+4.31.17+PM.png Blog - Don't try to cure cancer https://www.adanguyenx.com/blog/to-make-the-most-rational-decisions-use-your-gut monthly 0.5 2025-07-22 https://www.adanguyenx.com/blog/category/Biotech monthly 0.5 https://www.adanguyenx.com/blog/category/Blog monthly 0.5 https://www.adanguyenx.com/writing daily 0.75 2025-06-22 https://www.adanguyenx.com/longevity/genomic-instability daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574795757-K3RZYUSJLU12ISTNX76S/Genome+instability.png Genomic instability - Make it stand out Figure 1: Therapeutic approaches for genome instability. Areas with yellow highlight indicate target(s) not explored by existing companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574795762-6LWJEDBKIPHQSGDZE963/DNA+repair.png Genomic instability - Make it stand out Figure 2. DNA repair pathways (source: Vijg 2021) https://www.adanguyenx.com/longevity/pathological-cells daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574797828-3NQD80EYN4DZLZQL9N3W/Pathological.png Pathological cells - Make it stand out Figure 1: Therapeutic approaches for pathological cells. Areas with yellow highlight indicate target(s) not explored by existing companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://www.adanguyenx.com/longevity/dysbiosis daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574798658-MM9HNBUJMBQYJULOX3MM/Dysbiosis.png Dysbiosis - Make it stand out Figure 1: Therapeutic approaches for dysbiosis. Areas with yellow highlight indicate target(s) not explored by existing companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://www.adanguyenx.com/future daily 0.75 2025-06-22 https://www.adanguyenx.com/longevity/ecm daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574803149-KXXVMIVLRTLQ7YCOYY1H/ECM.png ECM stiffness - Make it stand out Figure 1: Therapeutic approaches for ECM stiffness. Areas with yellow highlight indicate target(s) not explored by existing companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://www.adanguyenx.com/partial-reprogramming-tables daily 0.75 2025-06-22 https://www.adanguyenx.com/start-here-1 daily 1.0 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574810819-36GW7QE9W6ASHW3J40DE/Headshot.png Start here - Hi, I’m Ada. https://www.adanguyenx.com/longevity/autophagy daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574811721-TDWPIIFJXEDEC2NETCZL/molce-41-1-65f1.jpeg Disabled macroautophagy - Make it stand out Figure 2. Autophagy process (source: Nakamura and Yoshimori 2018) https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574811718-24CTT3UGOK33332J2IIL/Disabled+macroautophagy.png Disabled macroautophagy - Make it stand out Figure 1: Therapeutic approaches for disabled macroautophagy. Areas with yellow highlight indicate target(s) not explored by existing companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://www.adanguyenx.com/longevity/altered-cellular-communication daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574812745-NPBJMNXC6DZXTOMLJQAK/Cell+comm.png Altered cellular communication - Make it stand out Figure 1: Therapeutic approaches for altered cellular communication. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574812749-9W5IY1F5PB8GZU33PNZF/parabiosis.png Altered cellular communication - Make it stand out Figure 2: good and bad circulating factors (Source: Rybtsova et al. 2020) https://www.adanguyenx.com/longevity daily 0.75 2025-06-22 https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813632-SD96XXFPFLSRP3MDTKQR/Discover.png Longevity Biotech Landscape - Make it stand out Figure 6. Overview of “Discover” companies. Company logo is followed by description of their approach, stage of development, and disease(s) they target. https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813628-VTX7WWC9ZJSAIRUFKNJO/Reprogram.png Longevity Biotech Landscape - Make it stand out Figure 5. Overview of “Reprogram” companies and their development stage https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813625-WEIISJQ7WQR1LJZBIKJD/Replace.png Longevity Biotech Landscape - Make it stand out Figure 4. Overview of “Replace” companies https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813614-KRKY1MUADGOLOHYPTKA7/Frame+23.png Longevity Biotech Landscape - Make it stand out Figure 1: Visual representation of the four main longevity biotech paradigms https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813618-RTEYBL1CMYN0R9GZ9XDW/Everything.png Longevity Biotech Landscape - Make it stand out Figure 2. Market map of all longevity biotech companies https://images.squarespace-cdn.com/content/v1/6857a6cb0bc3e85ce9c0196d/1750574813621-6QJMKS7Z49J3B0D7O39Y/Reset+and+Repair.png Longevity Biotech Landscape - Make it stand out Figure 3. Overview of “Reset and Repair” companies. Areas with yellow highlight indicate target(s) not explored by existing companies. Click on image to open a larger version in new tab.